Shunichi Takeda Selected Research

DNA Repair-Deficiency Disorders (Chromosome Instability Syndromes)

10/2021	Follow-up genotoxicity assessment of Ames-positive/equivocal chemicals using the improved thymidine kinase gene mutation assay in DNA repair-deficient human TK6 cells.
1/2020	Enhancing the sensitivity of the thymidine kinase assay by using DNA repair-deficient human TK6 cells.
1/2017	Selective cytotoxicity of the anti-diabetic drug, metformin, in glucose-deprived chicken DT40 cells.
12/2016	Determination of genotoxic potential by comparison of structurally related azo dyes using DNA repair-deficient DT40 mutant panels.
2/2016	Cytotoxic and genotoxic profiles of benzo[a]pyrene and N-nitrosodimethylamine demonstrated using DNA repair deficient DT40 cells with metabolic activation.
1/2016	Identification of genotoxic compounds using isogenic DNA repair deficient DT40 cell lines on a quantitative high throughput screening platform.
7/2014	Impact of DNA repair pathways on the cytotoxicity of piperlongumine in chicken DT40 cell-lines.
5/2014	Berberine induces double-strand DNA breaks in Rev3 deficient cells.
8/2011	Characterization of environmental chemicals with potential for DNA damage using isogenic DNA repair-deficient chicken DT40 cell lines.
5/2004	Extensive chromosomal breaks are induced by tamoxifen and estrogen in DNA repair-deficient cells.

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Shunichi Takeda Research Topics

Disease

33	Neoplasms (Cancer) 05/2022 - 09/2007
22	Hypersensitivity (Allergy) 01/2021 - 01/2002
12	Chromosome Aberrations (Chromosome Abnormalities) 05/2021 - 11/2006
10	DNA Repair-Deficiency Disorders (Chromosome Instability Syndromes) 10/2021 - 05/2004
8	Chromosome Breakage 07/2020 - 05/2004
7	Fanconi Anemia (Fanconi's Anemia) 12/2020 - 12/2007
6	Genomic Instability 07/2020 - 05/2008
5	Parkinson Disease (Parkinson's Disease) 10/2021 - 11/2009
4	Breast Neoplasms (Breast Cancer) 11/2018 - 05/2004
3	Lymphoma (Lymphomas) 01/2021 - 01/2007
3	Carcinogenesis 11/2018 - 02/2002
2	Gaucher Disease (Gaucher's Disease) 10/2021 - 04/2015
2	Prostatic Neoplasms (Prostate Cancer) 07/2020 - 01/2016
2	Chronic Hepatitis B 06/2019 - 01/2016
2	Infections 01/2019 - 09/2009
2	Carcinoma (Carcinomatosis) 09/2012 - 06/2003
2	Chromosomal Instability (Chromosome Stability) 12/2010 - 03/2007
2	Xeroderma Pigmentosum (Kaposi's Disease) 10/2010 - 12/2005
2	Ataxia Telangiectasia (Louis Bar Syndrome) 05/2008 - 06/2003
1	Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse) 01/2021
1	Cicatrix (Scar) 12/2020
1	Aplastic Anemia (Anemia, Hypoplastic) 12/2020
1	Pancytopenia 12/2020
1	Bone Marrow Failure Disorders 12/2020
1	Endometrial Neoplasms (Endometrial Cancer) 01/2020
1	Hepatitis B 06/2019
1	Liver Neoplasms (Liver Cancer) 01/2018
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/2018
1	Hypoxia (Hypoxemia) 01/2018
1	Lung Neoplasms (Lung Cancer) 11/2017

Drug/Important Bio-Agent (IBA)

22	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 02/2002
8	Proteins (Proteins, Gene)FDA Link 01/2018 - 06/2003
7	CamptothecinIBA 01/2020 - 01/2002
6	2- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA 01/2020 - 11/2006
6	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA 01/2015 - 06/2003
4	Methyl MethanesulfonateIBA 01/2021 - 01/2002
4	Cisplatin (Platino)FDA LinkGeneric 01/2021 - 10/2006
4	Poly(ADP-ribose) Polymerase InhibitorsIBA 02/2014 - 06/2011
3	Mitomycin (Mitomycin-C)FDA LinkGeneric 01/2020 - 12/2010
3	A-Form DNA (A-DNA)IBA 01/2020 - 04/2015
3	UbiquitinIBA 01/2019 - 09/2009
3	Pharmaceutical PreparationsIBA 04/2015 - 05/2012
2	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 05/2022 - 01/2018
2	olaparibIBA 05/2022 - 02/2014
2	talazoparibIBA 05/2022 - 02/2014
2	Thymidine KinaseIBA 10/2021 - 01/2020
2	Glucosylceramidase (Glucocerebrosidase)IBA 10/2021 - 04/2015
2	FlavonoidsIBA 05/2021 - 06/2020
2	Histone Deacetylase InhibitorsIBA 01/2021 - 01/2014
2	Type I DNA Topoisomerases (Topoisomerase I)IBA 01/2020 - 09/2014
2	Formaldehyde (Formol)FDA Link 01/2020 - 12/2007
2	nasIBA 06/2019 - 01/2016
2	ChromatinIBA 01/2019 - 06/2010
2	Estrogens (Estrogen)FDA Link 11/2018 - 05/2004
2	Metformin (Glucophage)FDA LinkGeneric 01/2018 - 01/2017
2	Adenosine Triphosphatases (ATPase)IBA 01/2018 - 01/2017
2	DNA-Binding Proteins (DNA Binding Protein)IBA 01/2018 - 05/2008
2	Glucose (Dextrose)FDA LinkGeneric 01/2018 - 01/2017
2	NucleosidesIBA 11/2017 - 01/2016
2	Reactive Oxygen Species (Oxygen Radicals)IBA 05/2016 - 08/2011
2	Etoposide (VP 16)FDA LinkGeneric 01/2016 - 01/2010
2	DNA HelicasesIBA 05/2014 - 09/2009
2	RecQ HelicasesIBA 05/2014 - 06/2012
2	hydroxide ionIBA 01/2014 - 06/2011
2	Proliferating Cell Nuclear Antigen (PCNA)IBA 01/2012 - 06/2011
2	Small Interfering RNA (siRNA)IBA 12/2010 - 03/2007
2	DNA-Directed DNA Polymerase (Polymerases, DNA)IBA 10/2010 - 12/2005
2	Proteasome Endopeptidase Complex (Proteasome)IBA 10/2010 - 09/2009
2	Phosphotransferases (Kinase)IBA 02/2010 - 05/2008
2	Proteasome InhibitorsIBA 09/2009 - 09/2007
1	Lomustine (CCNU)FDA Link 05/2022
1	Carmustine (FIVB)FDA Link 05/2022
1	PoisonsIBA 05/2022
1	Temozolomide (Temodar)FDA LinkGeneric 05/2022
1	SynucleinsIBA 10/2021
1	Biological ProductsIBA 05/2021
1	Histones (Histone)IBA 05/2021
1	ApigeninIBA 05/2021
1	flavoneIBA 05/2021
1	Messenger RNA (mRNA)IBA 01/2021
1	Cytarabine (Cytosar-U)FDA LinkGeneric 01/2021
1	tazemetostatIBA 01/2021
1	Exonucleases (3' 5' Exonuclease)IBA 01/2021
1	PanobinostatIBA 01/2021
1	carnosolIBA 08/2020
1	AndrogensIBA 07/2020
1	LuteolinIBA 06/2020
1	RibonucleotidesIBA 01/2020
1	adefovirIBA 06/2019
1	adefovir dipivoxil (Hepsera)FDA Link 06/2019
1	GenisteinIBA 01/2019
1	EnzymesIBA 01/2019
1	Phytoestrogens (Phytoestrogen)IBA 01/2019
1	Bromodeoxyuridine (BrdU)IBA 01/2018
1	Poly Adenosine Diphosphate RiboseIBA 01/2018
1	sapacitabineIBA 11/2017
1	2'- cyano- 2'- deoxyarabinofuranosylcytosineIBA 11/2017
1	ResveratrolIBA 08/2017

Therapy/Procedure

8	Therapeutics 12/2021 - 09/2009
1	Drug Therapy (Chemotherapy) 06/2020